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Multiple atherosclerosis-related biomarkers associated with short- and long-term mortality after stroke

Chan, Cangel Pui-yee, Jiang, Hui-lin, Leung, Ling-yan, Wan, Wai-man, Cheng, Nga-man, Ip, Wai-sze, Cheung, Kwan-yee, Chan, Rebecca Wing-yan, Wong, Lawrence Ka-sing, Graham, Colin Alexander, Renneberg, Reinhard and Rainer, Timothy 2012. Multiple atherosclerosis-related biomarkers associated with short- and long-term mortality after stroke. Clinical Biochemistry 45 (16-17) , pp. 1308-1315. 10.1016/j.clinbiochem.2012.06.014

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Abstract

We investigated the relationships of biomarkers of various pathophysiologic pathways including high-sensitivity C-reactive protein (hs-CRP), lipocalin-2 (LCN2), myeloperoxidase (MPO) and matrix metalloproteinases 9 (MMP9) with mortality in stroke patients. Design and methods hs-CRP, LCN2 and MPO concentrations in 92 patients were determined using enzyme-linked immunosorbent assays. MMP9 mRNA concentrations were determined using real-time quantitative reverse transcription-polymerase chain reaction. Results Twelve patients (13.0%) died at 6 months and 34 patients (37.0%) died at 5 years. The independent predictors for 6-month mortality were hs-CRP (adjusted OR = 16.0) and LCN2 (adjusted OR = 16.9), while for 5-year mortality was hs-CRP (adjusted OR = 5.56). For patients with hs-CRP > 3.4 mg/L, an increase in LCN2 was associated with 2.5-fold higher 6-month mortality, while an increase in normalized MMP9 mRNA was associated with 5.8-fold higher 6-month and 1.5-fold higher 5-year mortality. Conclusion hs-CRP was the most significant independent predictor of both short- and long-term mortality after stroke, with LCN2 and MMP9 mRNA each adding further to the risk stratification.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: High-sensitivity C-reactive protein (hs-CRP); Lipocalin-2 (LCN2); Matrix metalloproteinase 9 (MMP9); Mortality; Myeloperoxidase (MPO); Stroke
Publisher: Elsevier
ISSN: 0009-9120
Date of Acceptance: 10 June 2012
Last Modified: 04 Jun 2017 09:17
URI: http://orca-mwe.cf.ac.uk/id/eprint/93025

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