Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Early role of neutrophil l-selectin in posttraumatic acute lung injury

Rainer, Timothy, Lam, Nicole Y. L., Chan, Tina Y. F. and Cocks, Robert A. 2000. Early role of neutrophil l-selectin in posttraumatic acute lung injury. Critical Care Medicine 28 (8) , pp. 2766-2772. 10.1097/00003246-200008000-00014

Full text not available from this repository.


Objective: To investigate whether early numerical and functional changes in circulating neutrophils and expression of neutrophil l-selectin and soluble l-selectin are related to the subsequent development of posttraumatic acute lung injury (ALI), the systemic inflammatory response syndrome, sepsis, and organ failure. Design: Prospective study of whole blood and plasma samples to assess numerical and functional changes in circulating neutrophils and in soluble l-selectin. Setting: The emergency department of a university hospital. Patients: A total of 147 patients admitted to the resuscitation room after trauma were compared with 69 control subjects. Ten patients developed ALI. Laboratory Analysis: Flow cytometry of whole blood and ELISA of plasma. Results: Total leukocyte and neutrophil counts, expression of L-selectin, and the ratio of neutrophil to plasma L-selectin increased with injury and were highest in those who developed ALI. Soluble L-selectin decreased with injury severity and was lowest in those who developed ALI. Conclusions: Early changes in the average expression of L-selectin per cell do not correlate with the development of subsequent posttraumatic ALI. However, the development of ALI is related to the total expression of L-selectin in the neutrophil mass, and the most striking association is in those with lower concentrations of plasma L-selectin.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Lippincott Williams & Wilkins
ISSN: 0090-3493
Last Modified: 04 Jun 2017 09:16

Citation Data

Cited 26 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item