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Paraoxonase 1 gene Q192R polymorphism affects stroke and myocardial infarction risk

Baum, Larry, Ng, Ho Keung, Woo, Kam Sang, Tomlinson, Brian, Rainer, Timothy Hudson, Chen, Xiangyan, Cheung, Wing Sze, Yin Chan, Daniel Kam, Thomas, G. Neil, Wai Tong, Cindy See and Wong, Ka Sing 2006. Paraoxonase 1 gene Q192R polymorphism affects stroke and myocardial infarction risk. Clinical Biochemistry 39 (3) , pp. 191-195. 10.1016/j.clinbiochem.2006.01.010

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Abstract

Objectives: Paraoxonase (PON1), an enzyme associated with high-density lipoprotein (HDL) particles, inhibits oxidation and atherogenesis. We sought to investigate the association of the PON1 Q192R polymorphism with stroke and heart disease. Design and methods: In a case control study, we genotyped 242 ischemic stroke, 231 myocardial infarction (MI), and 310 healthy control subjects, all Chinese. Results: R-containing genotypes (R+) were associated with vascular disease, OR = 1.5, P = 0.03. RR was increased in MI patients who were either smokers (OR = 3.1, P = 0.01), male, or younger than 60. R+ but not RR genotypes were increased in stroke patients, particularly large artery type (OR = 2.6 and P = 0.02 for R+, OR = 1.0 for RR) or among smokers. The relative dearth of RR in stroke might be due to earlier MI or death in at-risk people, such as smokers. R+ genotypes were increased with stroke in hypertensive (OR = 2.1, P = 0.02) but not normotensive (OR = 1.0) subjects. Conclusions: PON1 192R+ genotypes were associated with stroke and MI, particularly in subsets of patients, in patterns suggesting a possible survivor effect.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Paraoxonase; Polymorphism; Ischemic stroke; Myocardial infarction
Publisher: Elsevier
ISSN: 0009-9120
Date of Acceptance: 2 January 2006
Last Modified: 04 Jun 2017 09:15
URI: http://orca-mwe.cf.ac.uk/id/eprint/92863

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