Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Protection from traumatic brain injury in hormonally active women vs men of a similar age: A retrospective international study

Yeung, J.H.H., Mikocka-Walus, A.A., Cameron, P.A., Poon, W.S., Ho, H.F., Chang, A., Graham, C.A. and Rainer, Timothy 2011. Protection from traumatic brain injury in hormonally active women vs men of a similar age: A retrospective international study. Archives of Surgery 146 (4) , pp. 436-442. 10.1001/archsurg.2011.46

Full text not available from this repository.

Abstract

BACKGROUND: It has been suggested that women with traumatic brain injury have more favorable outcomes than do men because of higher levels of circulating estrogen and progesterone that may reduce brain edema. OBJECTIVES: To determine whether there is any association between sex and mortality in TBI patients and whether there is any association between sex and brain edema. DESIGN: Retrospective cohort study using data from 2001 to 2007 collected from a trauma registry in Hong Kong and the Victorian State Trauma Registry. SETTING: Two regional trauma centers in Hong Kong and 2 adult major trauma centers and 1 pediatric trauma center in Victoria, Australia. MAIN OUTCOME MEASURES: Mortality and brain edema. PATIENTS: Trauma patients with an Abbreviated Injury Scale score (head) of at least 3 who were aged 12 to 45 years were included. Patients with minor head injury and undisplaced closed skull fracture were excluded. RESULTS: Both the Hong Kong and Victorian data showed no significant difference in sex-related mortality. Increased mortality was associated with decreased systolic blood pressure and Glasgow Coma Scale score and with increased New Injury Severity Score or Injury Severity Score. In Hong Kong, brain edema was associated with female sex (P = .02), and the odds of brain edema in females were greater than for males. However, this association was not found in Victorian patients. CONCLUSION: This study found no significant association between sex and mortality in either Victoria or Hong Kong and does not support the concept that females have better outcomes after traumatic brain injury.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: American Medical Association
ISSN: 0004-0010
Date of Acceptance: 19 March 2010
Last Modified: 04 Jun 2017 09:15
URI: http://orca-mwe.cf.ac.uk/id/eprint/92703

Citation Data

Cited 20 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item