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Pathophysiological roles and clinical importance of biomarkers in acute coronary syndrome

Chan, Cangel Pui-yee and Rainer, Timothy 2013. Pathophysiological roles and clinical importance of biomarkers in acute coronary syndrome. In: Makowski, Gregory S. ed. Advances in Clinical Chemistry, Vol. 59. Elsevier, pp. 23-63. (10.1016/B978-0-12-405211-6.00002-4)

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Early diagnosis of acute coronary syndrome (ACS) is important to guide appropriate therapy at a time when it is most likely to be of value. Accurate prognostic and risk stratification will facilitate high-risk patients to have early advanced diagnostic investigations and early appropriate interventions in a cost-effective and efficient manner, while those patients at low risk of ACS complications do not need such costly diagnostic tests and unnecessary hospital admission. Recent investigations have demonstrated that elevation of biomarkers upstream from acute-phase biomarkers, biomarkers of plaque destabilization and rupture, biomarkers of myocardial ischemia, necrosis, and dysfunction may provide an earlier assessment of patient risk and identify patients with higher risk of having an adverse event. This review provides an overview of the pathophysiology and clinical characteristics of several well-established biomarkers as well as emerging biomarkers that may have potential clinical utility in patients with ACS. Such emerging biomarkers hold promise and need to be more thoroughly evaluated before utilization in routine clinical practice.

Item Type: Book Section
Status: Published
Schools: Medicine
Uncontrolled Keywords: B-type natriuretic peptide; C-reactive protein; Cardiac troponins; Choline; Creatine kinase MB; Heart-type fatty acid-binding protein; Ischemia-modified albumin; Matrix metalloproteinase 9; Myeloperoxidase; Myoglobin; Neopterin; Pregnancy-associated plasma protein A; Soluble CD40 ligand
Publisher: Elsevier
ISBN: 9780124052116
ISSN: 00652423
Last Modified: 04 Jun 2017 09:15

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