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A peptide derived from Activity-Dependent Neuroprotective Protein (ADNP) ameliorates injury response in closed head injury in mice

Beni-Adani, Laura, Gozes, Illana, Cohen, Yoram, Assaf, Yaniv, Steingart, Ruth A., Brenneman, Douglas E., Eizenberg, Oded, Trembolver, Victoria and Shohami, Esther 2001. A peptide derived from Activity-Dependent Neuroprotective Protein (ADNP) ameliorates injury response in closed head injury in mice. Journal of Pharmacology and Experimental Therapeutics 296 (1) , pp. 57-63.

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Abstract

Brain injury induces disruption of the blood-brain barrier, edema, and release of autodestructive factors that produce delayed neuronal damage. NAPSVIPQ (NAP), a femtomolar-acting peptide, is shown to be neuroprotective in a mouse model of closed head injury. NAP injection after injury reduced mortality and facilitated neurobehavioral recovery (P < 0.005). Edema was reduced by 70% in the NAP-treated mice (P < 0.01). Furthermore, in vivo magnetic resonance imaging demonstrated significant brain-tissue recovery in the NAP-treated animals. NAP treatment decreased tumor necrosis factor-α levels in the injured brain and was shown to protect pheochromocytoma (PC12 cells) against tumor necrosis factor-α-induced toxicity. Thus, NAP provides significant amelioration from the complex array of injuries elicited by head trauma.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Neuroscience and Mental Health Research Institute (NMHRI)
Publisher: HighWire Press
ISSN: 0022-3565
Last Modified: 21 Aug 2019 02:18
URI: http://orca-mwe.cf.ac.uk/id/eprint/91833

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