Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities

Quiñones-Parraa, Sergio, Grant, Emma, Loha, Liyen, Nguyena, Thi H. O., Campbell, Kirsty-Anne, Tong, Steven Y. C., Miller, Adrian, Doherty, Peter C., Vijaykrishnag, Dhanasekaran, Rossjohn, Jamie, Gras, Stephanie and Kedzierskaa, Katherine 2014. Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities. Proceedings of the National Academy of Sciences of the United States of America 111 (3) , pp. 1049-1054. 10.1073/pnas.1322229111

Full text not available from this repository.

Abstract

The absence of preexisting neutralizing antibodies specific for the novel A (H7N9) influenza virus indicates a lack of prior human exposure. As influenza A virus–specific CD8+ T lymphocytes (CTLs) can be broadly cross-reactive, we tested whether immunogenic peptides derived from H7N9 might be recognized by memory CTLs established following infection with other influenza strains. Probing across multiple ethnicities, we identified 32 conserved epitopes derived from the nucleoprotein (NP) and matrix-1 (M1) proteins. These NP and M1 peptides are presented by HLAs prevalent in 16–57% of individuals. Remarkably, some HLA alleles (A*0201, A*0301, B*5701, B*1801, and B*0801) elicit robust CTL responses against any human influenza A virus, including H7N9, whereas ethnicities where HLA-A*0101, A*6801, B*1501, and A*2402 are prominent, show limited CTL response profiles. By this criterion, some groups, especially the Alaskan and Australian Indigenous peoples, would be particularly vulnerable to H7N9 infection. This dissection of CTL-mediated immunity to H7N9 thus suggests strategies for both vaccine delivery and development.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: CD8 T cells; HLA types
Publisher: National Academy of Sciences
ISSN: 0027-8424
Last Modified: 07 Feb 2019 11:49
URI: http://orca-mwe.cf.ac.uk/id/eprint/90755

Citation Data

Cited 74 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item