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Functional group/guild modelling of inter-specific pathogen interactions: A potential tool for predicting the consequences of co-infection

Lello, Joanne and Hussell, T. 2008. Functional group/guild modelling of inter-specific pathogen interactions: A potential tool for predicting the consequences of co-infection. Parasitology 135 (7) , pp. 825-839. 10.1017/S0031182008000383

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Abstract

Although co-infection is the norm in most human and animal populations, clinicians currently have no practical tool to assist them in choosing the best treatment strategy for such patients. Given the vast range of potential pathogens which may co-infect the host, obtaining such a practical tool may seem an intractable problem. In ecology the joint concepts of functional groups and guilds have been used to conceptually simplify complex ecosystems, in order to understand how their component parts interact and may be manipulated. Here we propose a mechanism by which to apply these concepts to pathogen co-infection systems. Further, we describe how these groups could be incorporated into a mathematical modelling framework which, after validation, could be used as a clinical tool to predict the outcome of any particular combination of pathogens co-infecting a host.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Additional Information: Pdf uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/0031-1820/ (accessed 24/02/2014).
Publisher: Cambridge University Press
ISSN: 0031-1820
Date of First Compliant Deposit: 30 March 2016
Last Modified: 04 Jun 2017 02:06
URI: http://orca-mwe.cf.ac.uk/id/eprint/8946

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Cited 12 times in Google Scholar. View in Google Scholar

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