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Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro

Patin, Emmanuel C., Willcocks, Sam, Orr, Selinda Jane, Ward, Theresa H., Lang, Roland and Schaible, Ulrich E. 2016. Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro. Innate Immunity 22 (3) , pp. 181-185. 10.1177/1753425916636671

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The role of macrophage-inducible C-type lectin (Mincle) in anti-inflammatory responses has not yet been fully characterized. Herein, we show that engagement of Mincle by trehalose-dimycolate or mycobacteria promotes IL-10 production in macrophages, which causes down-regulation of IL-12p40 secretion. Thus, Mincle mediates both pro- as well as anti-inflammatory responses.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: Q Science > Q Science (General)
Publisher: SAGE Publications
ISSN: 1753-4259
Funders: Wellcome Trust, Royal Society
Date of First Compliant Deposit: 7 April 2016
Date of Acceptance: 27 January 2016
Last Modified: 17 Jun 2019 13:54

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