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Hepatocyte growth factor activators, inhibitors and antagonists and their implication in cancer intervention.

Parr, Christian and Jiang, Wen Guo 2001. Hepatocyte growth factor activators, inhibitors and antagonists and their implication in cancer intervention. Histology and Histopathology 16 (1) , pp. 251-268.

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Abstract

Hepatocyte growth factor (HGF), otherwise known as scatter factor (SF), has been demonstrated over the past decade to elicit a number of functions that may be tumorigenic, and enhance the invasive/metastatic nature of cancer cells. Clinical studies have also demonstrated that HGF/SF, together with its receptor, cMET, is closely related to the disease progression and prognosis of patients with cancer. The past few years have seen the identification of numerous inhibitors and antagonists to the action of HGF/SF. These factors have demonstrated a possible role in minimising the action of HGF/SF on cancer cells, and may be of therapeutic value in the future. This article overviews the activators, inhibitors, and antagonists to HGF/SF and discusses the possible implications in cancer therapy.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Hernández
ISSN: 0213-3911
Last Modified: 04 Jun 2017 08:59
URI: http://orca-mwe.cf.ac.uk/id/eprint/88810

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