Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Regulation of spreading and growth of colon cancer cells by hepatocyte growth factor.

Jiang, Wen Guo, Lloyds, David, Puntis, Malcolm C. A., Nakamura, T. and Hallett, Maurice Bartlett 1993. Regulation of spreading and growth of colon cancer cells by hepatocyte growth factor. Clinical and Experimental Metastasis 11 (3) , pp. 235-242. 10.1007/BF00121166

Full text not available from this repository.

Abstract

Hepatocyte growth factor (HGF), also known as scatter factor, regulates both cell motility and the growth of some cell types. We have determined the effects of HGF on the motility and growth of human colon cancer cell lines (HT115, HT29, HRT18 and HT55). Cell motility, as measured by dissociation from carrier beads or by scattering of cell colonies, was greatly increased in all cell lines. The effects were completely blocked by anti-HGF antibody. In contrast, cell growth of HT115, HT29 and HRT18 cells was inhibited by a wide range of concentrations of HGF. HT55 cell growth was also inhibited but needed a prolonged culture period (> 5 days). The HGF receptor/Met protein is highly expressed in the membrane fraction of these cells as determined by Western blotting. It is concluded that HGF has an effect on both colon cancer cell motility and growth, which may be important in the control of the spread of colon cancer.

Item Type: Article
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: cell growth cell motility c-MET protooncogene colon cancer cell hepatocyte growth factor scatter factor
Publisher: Springer Verlag
ISSN: 0262-0898
Date of Acceptance: 6 January 1993
Last Modified: 04 Jun 2017 08:59
URI: http://orca-mwe.cf.ac.uk/id/eprint/88744

Citation Data

Cited 80 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item