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Cellular and molecular mechanisms of repair in acute and chronic wound healing

Martin, Paul and Nunan, R. 2015. Cellular and molecular mechanisms of repair in acute and chronic wound healing. British Journal of Dermatology 173 (2) , pp. 370-378. 10.1111/bjd.13954

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Abstract

A considerable understanding of the fundamental cellular and molecular mechanisms underpinning healthy acute wound healing has been gleaned from studying various animal models, and we are now unravelling the mechanisms that lead to chronic wounds and pathological healing including fibrosis. A small cut will normally heal in days through tight orchestration of cell migration and appropriate levels of inflammation, innervation and angiogenesis. Major surgeries may take several weeks to heal and leave behind a noticeable scar. At the extreme end, chronic wounds – defined as a barrier defect that has not healed in 3 months – have become a major therapeutic challenge throughout the Western world and will only increase as our populations advance in age, and with the increasing incidence of diabetes, obesity and vascular disorders. Here we describe the clinical problems and how, through better dialogue between basic researchers and clinicians, we may extend our current knowledge to enable the development of novel potential therapeutic treatments.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RL Dermatology
Publisher: Wiley-Blackwell
ISSN: 0007-0963
Date of Acceptance: 13 May 2015
Last Modified: 12 Jun 2019 09:49
URI: http://orca-mwe.cf.ac.uk/id/eprint/85576

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