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Modulation of Candida albicansvirulence by bacterial biofilms on titanium surfaces

Cavalcanti, Yuri Wanderley, Wilson, Melanie, Lewis, Michael Alexander Oxenham, Del-Bel-Cury, Altair Antoninha, da Silva, Wander José and Williams, David Wynne 2016. Modulation of Candida albicansvirulence by bacterial biofilms on titanium surfaces. Biofouling 32 (2) , pp. 123-134. 10.1080/08927014.2015.1125472

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Abstract

Whilst Candida albicans occurs in peri-implant biofilms, its role in peri-implantitis remains unclear. This study therefore examined the virulence of C. albicans in mixed-species biofilms on titanium surfaces. Biofilms of C. albicans (Ca), C. albicans with streptococci (Streptococcus sanguinis, S. mutans) (Ca-Ss-Sm) and those incorporating Porphyromonas gingivalis (Ca-Pg and Ca-Ss-Sm-Pg) were developed. Expression of C. albicans genes associated with adhesion (ALS1, ALS3, HWP1) and hydrolytic enzymes (SAP2, SAP4, SAP6, PLD1) was measured and hyphal production by C. albicans quantified. Compared with Ca biofilms, significant (p<0.05) up-regulation of ALS3, HWP1, SAP2 and SAP6, and hyphal production occurred in biofilms containing streptococci (Ca-Ss-Sm). In Ca-Pg biofilms, down-regulation of HWP1 and SAP4 expression, with reduced hyphal production occurred. Ca-Ss-Sm-Pg biofilms had increased hyphal proportions and up-regulation of ALS3, SAP2 and SAP6. In conclusion, C. albicans expressed virulence factors in biofilms that could contribute to peri-implantitis, but this was dependent on associated bacterial species.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Subjects: R Medicine > RK Dentistry
Publisher: Taylor & Francis
ISSN: 0892-7014
Date of Acceptance: 23 November 2015
Last Modified: 28 May 2019 12:45
URI: http://orca-mwe.cf.ac.uk/id/eprint/85573

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