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The stimulus-induced release of 5-hydroxytryptamine and tryptophan from superfused rat brain synaptosomes

Collard, K. J., Evans, T. N. W., Suter, H. A. and Wilkinson, Lawrence Stephen 1982. The stimulus-induced release of 5-hydroxytryptamine and tryptophan from superfused rat brain synaptosomes. Journal of Neural Transmission 53 (2-3) , pp. 223-230. 10.1007/BF01243414

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Abstract

The synthesis of 5-hydroxytryptamine (5-HT) from3H-tryptophan in rat forebrain synaptosomes was studied. Synaptosomes which had been preincubated with3H-tryptophan were perfused with Krebs solution and the release of tryptophan, 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) was determined. K+ depolarization induced a Ca2+-dependent release of 5-HT and tryptophan but had no effect on 5-HIAA efflux. This finding suggests that the release of tryptophan is unlikely to be a non-specific effect of depolarization.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Psychology
Subjects: R Medicine > R Medicine (General)
Publisher: Springer Verlag
ISSN: 0300-9564
Last Modified: 04 Jun 2017 08:49
URI: http://orca-mwe.cf.ac.uk/id/eprint/85465

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