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Multicenter linkage study of schizophrenia loci on chromosome 22q

Mowry, B J, Holmans, Peter Alan, Pulver, A E, Gejman, P V, Riley, B, Williams, Nigel Melville, Laurent, C, Schwab, S G, Wildenauer, D B, Bauché, S, Owen, Michael John, Wormley, B, Sanders, A R, Nestadt, G, Liang, K Y, Duan, J, Ribble, R, Norton, N, Soubigou, S, Maier, W, Ewen-White, K R, deMarchi, N, Carpenter, B, Walsh, D, Williams, H, Jay, M, Albus, M, Nertney, D A, Papadimitriou, G, O'Neill, A, O'Donovan, Michael Conlon, Deleuze, J-F, Lerer, F B, Dikeos, D, Kendler, K S, Mallet, J, Silverman, J M, Crowe, R R and Levinson, D F 2004. Multicenter linkage study of schizophrenia loci on chromosome 22q. Molecular Psychiatry 9 (8) , pp. 784-795. 10.1038/sj.mp.4001481

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Abstract

The hypothesis of the existence of one or more schizophrenia susceptibility loci on chromosome 22q is supported by reports of genetic linkage and association, meta-analyses of linkage, and the observation of elevated risk for psychosis in people with velocardiofacial syndrome, caused by 22q11 microdeletions. We tested this hypothesis by evaluating 10 microsatellite markers spanning 22q in a multicenter sample of 779 pedigrees. We also incorporated age at onset and sex into the analysis as covariates. No significant evidence for linkage to schizophrenia or for linkage associated with earlier age at onset, gender, or heterogeneity across sites was observed. We interpret these findings to mean that the population-wide effects of putative 22q schizophrenia susceptibility loci are too weak to detect with linkage analysis even in large samples.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Neuroscience and Mental Health Research Institute (NMHRI)
Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
Publisher: Nature Publishing Group: Open Access Hybrid Model Option B
ISSN: 1359-4184
Last Modified: 21 Jun 2019 20:45
URI: http://orca-mwe.cf.ac.uk/id/eprint/83563

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