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NPY mediates basal and seizure-induced proliferation in the subcallosal zone

Laskowski, Alexandra, Howell, Owain W., Sosuov, Alexander A., McKhann, Guy and Gray, William Peter 2007. NPY mediates basal and seizure-induced proliferation in the subcallosal zone. NeuroReport 18 (10) , pp. 1005-1008. 10.1097/WNR.0b013e32815277ab

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Abstract

Stem cell niches exist around the lateral ventricle and in the subgranular layer of the dentate gyrus, supporting adult neurogenesis. Recently, a third germinal layer, the subcallosal zone has been identified supporting the generation of oligodendrocytes in the adult brain. We have previously described a proliferative role for neuropeptide Y on precursors in the dentate gyrus, caudal subventricular zone and subcallosal zone under basal conditions and in the dentate gyrus after seizures. Here we sought to determine a role for neuropeptide Y in seizure-induced proliferation in the subcallosal niche. Using the chemoconvulsant kainate and neuropeptide Y(-/-) mice with controls, we show an effect of neuropeptide Y on basal proliferation and demonstrate a significant reduction in seizure-induced proliferation in the subcallosal zone.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Lippincott, Williams & Wilkins
ISSN: 0959-4965
Last Modified: 04 Jun 2017 08:42
URI: http://orca-mwe.cf.ac.uk/id/eprint/83036

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