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The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing-remitting multiple sclerosis

Frisullo, Giovanni, Mirabella, Massimiliano, Angelucci, Francesco, Caggiula, Marcella, Morosetti, Roberta, Sancricca, Cristina, Patanella, Agata Katia, Nociti, Viviana, Iorio, Raffaele, Bianco, Assunta, Tomassini, Valentina, Pozzilli, Carlo, Tonali, Pietro Attilio, Matarese, Giuseppe and Batocchi, Anna Paola 2007. The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing-remitting multiple sclerosis. Journal of Neuroimmunology 192 (1-2) , pp. 174-183. 10.1016/j.jneuroim.2007.08.008

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Abstract

In this study we observed higher serum leptin levels in relapsing-remitting multiple sclerosis (RRMS) patients during remission than in controls. The expression of leptin receptor (ObR) was higher in CD8+ T cells and monocytes from RRMS patients in relapse than in patients in remission and in controls. Relapsing patients showed high levels of pSTAT3 and low expression of SOCS3 and leptin administration induced an up-regulation of pSTAT3 only in monocytes from patients in relapse. Our data suggest that ObR may be involved in the development of clinical relapses in RRMS patients and suggest a rationale for potential targeting of the leptin axis during MS.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Elsevier
ISSN: 0165-5728
Last Modified: 20 Jun 2020 15:05
URI: http://orca-mwe.cf.ac.uk/id/eprint/82969

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