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Dopamine transporter gene (DAT1) VNTR polymorphism in major psychiatric disorders: family-based association study in the Bulgarian population

Georgieva, Lyudmila, Dimitrova, A., Nikolov, I., Koleva, S., Tsvetkova, R., Owen, Michael John, Toncheva, D. and Kirov, George 2002. Dopamine transporter gene (DAT1) VNTR polymorphism in major psychiatric disorders: family-based association study in the Bulgarian population. Acta Psychiatrica Scandinavica 105 (5) , pp. 396-399. 10.1034/j.1600-0447.2002.1o174.x

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Abstract

Objective: A 40-bp variable number tandem repeat in the 3′-UTR of dopamine transporter gene (DAT1) has been examined for association with major psychiatric disorders in several case–control studies. No significant results have been found. We used a new collection of parent–offspring trios to test for association with schizophrenia (SZ), bipolar 1 disorder (BPI) and schizoaffective (SA) disorder. Method: We genotyped trios from Bulgarian origin where the proband had SZ (178 trios), BPI (77 trios) and SA (29 trios). Alleles ranging from 5 to 11 repeats were observed. The results were analysed with the extended TDT (ETDT). Results: No preferential transmission of alleles was observed for any diagnostic group. The presence of allele DAT*10 was associated with the severity and frequency of auditory hallucinations, however, this result is not significant if corrected for multiple testing. Conclusion: Our results are in agreement with previous reports of a lack of association between this polymorphism and major psychiatric disorders.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Publisher: Wiley-Blackwell
ISSN: 0001-690X
Last Modified: 30 Oct 2017 13:17
URI: http://orca-mwe.cf.ac.uk/id/eprint/82475

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