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Sequence of the human homologue of a mitochondrially encoded murine transplantation antigen in patients with multiple sclerosis

Chalmers, R. M., Robertson, Neil, Kellar-Wood, H., Compston, D. A. and Harding, A. E. 1995. Sequence of the human homologue of a mitochondrially encoded murine transplantation antigen in patients with multiple sclerosis. Journal of Neurology 242 (5) , pp. 332-334. 10.1007/BF00878877

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Abstract

There is some evidence that mitochondrial genes may contribute to susceptibility to multiple sclerosis (MS), and a mitochondrial DNA-encoded peptide, the N-terminal portion of NADH-dehydrogenase subunit 1, acts as a transplantation antigen in mice. We have analysed the DNA sequence of the corresponding region of human mitochondrial DNA in 87 patients with MS, 10 with Leber's hereditary optic neuropathy in association with an MS-like illness, and 31 control subjects. This sequence appears to be highly conserved. Only three base pair changes were identified, each being found once only in one control and two patients, and these are likely to be harmless polymorphisms. There is thus no evidence that polymorphism in this region contributes to genetic susceptibility in MS.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Springer
ISSN: 0340-5354
Last Modified: 04 Jun 2017 08:39
URI: http://orca-mwe.cf.ac.uk/id/eprint/82272

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