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Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine

Arranz, M. J., Collier, D. A., Munro, J., Sham, P., Kirov, George, Sodhi, M., Roberts, G., Price, J. and Kerwin, R. W. 1996. Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine. Neuroscience Letters 217 (2-3) , pp. 177-178. 10.1016/0304-3940(96)13094-9

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Abstract

Clozapine is an atypical antipsychotic with affinity for a broad range of receptors, including serotonin (5-HT) and dopamine receptors. It is successful in treating about 60% of patients refractory to other antipsychotic drugs. Since genetic variation in clozapine's neurotransmitter receptor targets may affect clinical response through altering drug binding or receptor expression, we have studied a His452Tyr polymorphism in the 5-HT2A receptor (HTR2A) in a sample of 153 schizophrenic patients undergoing clozapine treatment and 178 normal controls. An association was found between the allele Tyr452 and poor clinical response.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
Publisher: Elsevier Scientific Publishers Ireland
ISSN: 0304-3940
Last Modified: 04 Jun 2017 08:39
URI: http://orca-mwe.cf.ac.uk/id/eprint/82018

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