Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Association between schizophrenia and a microsatellite polymorphism at the dopamine D5 receptor gene

Williams, Nigel Melville, Cardno, A. G., Murphy, K. C., Jones, L. A., Asherson, P., McGuffin, P. and Owen, Michael John 1997. Association between schizophrenia and a microsatellite polymorphism at the dopamine D5 receptor gene. Psychiatric Genetics 7 (2) , pp. 83-85. 10.1097/00041444-199722000-00005

Full text not available from this repository.

Abstract

An association study of 97 patients with DSM-III-R schizophrenia and 97 matched controls was performed using a polymorphic microsatellite repeat at the dopamine D5 receptor gene. We observed a significant difference between the allele frequencies of patients and controls (chi 2 = 23.4, df = 12, p = 0.019). This reflects an excess of allele 4 (140 bp) in the patients when compared with the control sample (chi 2 = 7.087, p < 0.01; odds ratio = 2.98, 95% CI 1.29-6.86). However, this association remains tentative until confirmation in other samples.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Lippincott Williams & Wilkins
ISSN: 0955-8829
Last Modified: 24 Jan 2018 21:36
URI: http://orca-mwe.cf.ac.uk/id/eprint/81853

Actions (repository staff only)

Edit Item Edit Item