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beta-dystrobrevin, a member of the dystrophin-related protein family

Blake, Derek J, Nawrotzki, R., Loh, N. Y., Gorecki, D. C. and Davies, K. E. 1998. beta-dystrobrevin, a member of the dystrophin-related protein family. Proceedings of the National Academy of Sciences of the United States of America 95 (1) , pp. 241-246. 10.1073/pnas.95.1.241

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Abstract

The importance of dystrophin and its associated proteins in normal muscle function is now well established. Many of these proteins are expressed in nonmuscle tissues, particularly the brain. Here we describe the characterization of beta-dystrobrevin, a dystrophin-related protein that is abundantly expressed in brain and other tissues, but is not found in muscle. beta-dystrobrevin is encoded by a 2.5-kb alternatively spliced transcript that is found throughout the brain. In common with dystrophin, beta-dystrobrevin is found in neurons of the cortex and hippocampal formation but is not found in the brain microvasculature. In the brain, beta-dystrobrevin coimmunoprecipitates with the dystrophin isoforms Dp71 and Dp140. These data provide evidence that the composition of the dystrophin-associated protein complex in the brain differs from that in muscle. This finding may be relevant to the cognitive dysfunction affecting many patients with Duchenne muscular dystrophy.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: National Academy of Sciences
ISSN: 0027-8424
Last Modified: 04 Jun 2017 08:38
URI: http://orca-mwe.cf.ac.uk/id/eprint/81759

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