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Dysbindin-1 and schizophrenia: from genetics to neuropathology

Owen, Michael John, Williams, Nigel Melville and O'Donovan, Michael Conlon 2004. Dysbindin-1 and schizophrenia: from genetics to neuropathology. The Journal of Clinical Investigation 113 (9) , pp. 1255-1257. 10.1172/JCI200421470

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Abstract

The gene encoding dysbindin-1 has recently been implicated in susceptibility to schizophrenia. In this issue of the JCI, Talbot et al. show that, contrary to expectations, dysbindin-1 is located presynaptically in glutamatergic neurons and is reduced at these locations in schizophrenia. Further studies of dysbindin-1 and the proteins with which it interacts can be expected to throw light on the pathogenesis of schizophrenia.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Publisher: American Society for Clinical Investigation
ISSN: 0021-9738
Last Modified: 24 Jan 2018 21:32
URI: http://orca-mwe.cf.ac.uk/id/eprint/81686

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