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Factor-derived subsyndromes of schizophrenia and familial morbid risks

Cardno, Alastair, Holmans, Peter Alan, Harvey, I., Williams, M. B., Owen, Michael John and McGuffin, P. 1996. Factor-derived subsyndromes of schizophrenia and familial morbid risks. Schizophrenia Research 18 (2-3) , IVA2-IVA2.

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Abstract

Factor analysis was performed on OPCRIT checklist ratings from 66 patients with RDC schizophrenia. Eight substantive factors were found, characterised respectively by: positive formal thought disorder; first rank delusions; first rank hallucinations; inappropriate affect/bizarre behaviour; negative symptoms; grandiose/bizarre delusions; delusions of influence/persecution; and other hallucinations. A history of schizophrenia and other non-affective psychoses was ascertained in the probands' first-degree relatives using a family history approach. Illness in relatives was best predicted by probands' scores on subsyndromes derived from the inappropriate affect/bizarre behaviour and positive formal thought disorder factors.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Publisher: Elsevier
ISSN: 0920-9964
Last Modified: 02 May 2019 12:49
URI: http://orca-mwe.cf.ac.uk/id/eprint/81626

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