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Thyrotropin cross-links to the thyrotropin receptor through both the alpha and beta subunits

Buckland, Paul Robert, Rickards, C R, Howells, R D and Smith, B R 1986. Thyrotropin cross-links to the thyrotropin receptor through both the alpha and beta subunits. Biochemical Journal 235 (3) , pp. 879-882. 10.1042/bj2350879

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Abstract

We have recently shown that the beta subunit of thyrotropin (TSH) can be cross-linked to the TSH receptor [Buckland, Strickland, Pierce & Rees Smith (1985) Endocrinology (Baltimore) 116, 2122-2124; Buckland, Strickland & Rees Smith (1985) Biochem. Soc. Trans. 13, 942-943]. We failed, however, to cross-link the alpha subunit to the receptor, leaving the role of this subunit in the TSH-TSH-receptor interaction uncertain. We now report the successful cross-linking of the TSH alpha subunit to the receptor by the use of two different cross-linking reagents. Our studies suggest therefore that both subunits of TSH form part of the hormone's receptor-binding site.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Biochemical Society
ISSN: 0264-6021
Last Modified: 04 Jun 2017 08:37
URI: http://orca-mwe.cf.ac.uk/id/eprint/81246

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