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The Circadian System and Affective Disorders: Clocks or Rhythms?

Healy, David and Waterhouse, James M. 1990. The Circadian System and Affective Disorders: Clocks or Rhythms? Chronobiology International 7 (1) , pp. 5-10. 10.3109/07420529009056947

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There have been a number of proposals that a pathology of the circadian system involving clock functioning underlies the affective disorders. It is argued that neither current findings from research into the neurophysiological substrates of the affective disorders, recent clinical findings regarding these illnesses or their phenomenology support such a contention. This does not mean however that there is not a primary pathological disturbance of the circadian system at the heart of the affective disorders. The same neurophysiological, phenomenological and clinical evidence can be offered in favour of a disturbance of circadian rhythms in the presence of grossly normal clock functioning. The research and remedial implications of this alternative are outlined briefly.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
Publisher: Marcel Dekker
ISSN: 0742-0528
Last Modified: 03 Dec 2015 12:19

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