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Physical mapping around the Alzheimer disease locus on the proximal long arm of chromosome 21.

Owen, Michael John, James, L.A., Hardy, J.A., Williamson, R and Goate, A.M. 1990. Physical mapping around the Alzheimer disease locus on the proximal long arm of chromosome 21. American Journal of Human Genetics 46 (2) , pp. 316-322.

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Abstract

Evidence from linkage studies suggests that familial Alzheimer disease (AD) can be caused by a defect in a gene on the proximal long arm of chromosome 21. We have constructed a physical map spanning 10 megabases of this region of the chromosome by means of pulsed-field gel electrophoresis and analysis of somatic cell hybrids. Our data have allowed us to establish the order of chromosome 21 loci--cen-(S16,S48)-S13-S46-S4-(S52,S110)-(S1,S1 1)--and are thus of immediate relevance both to multipoint linkage analysis in families affected by AD and for moving from this linkage to the isolation of the genetic defect. We have also been able to identify several CpG-rich sequences close to the four most centromeric loci, suggesting the location of genes in this region. These probes, which are all within 1.5 megabases of one another, are currently the markers most tightly linked to the AD locus. Genes identified in this region can therefore be considered as candidates for the disease locus.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Publisher: American Society of Human Genetics
ISSN: 0002-9297
Last Modified: 04 Jun 2017 08:36
URI: http://orca-mwe.cf.ac.uk/id/eprint/81109

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