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Genetic association studies of alcoholism--problems with the candidate gene approach

Buckland, Paul Robert 2001. Genetic association studies of alcoholism--problems with the candidate gene approach. Alcohol and Alcoholism 36 (2) , pp. 99-103. 10.1093/alcalc/36.2.99

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Abstract

In recent years, progress has been made in the identification of causative factors in most single gene disorders and those with genes of major effect. In comparison, no genes contributing to a complex disorder have been unambiguously identified. A number of reasons for this have been previously presented in theoretical papers. Alcoholism is such a complex illness and genetic studies into its underlying genetic causes have suffered from lack of power due to small subject numbers, poor selection of control subjects, and over-emphasis on markers with low prior probability of involvement.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Oxford University Press
ISSN: 0735-0414
Last Modified: 04 Jun 2017 08:36
URI: http://orca-mwe.cf.ac.uk/id/eprint/80893

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