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Psychiatric symptoms and CAG repeats in neurologically asymptomatic Huntington's disease gene carriers

Berrios, G. E., Wagle, A. C., Markova, I. S., Wagle, S. A., Ho, L. W., Rubinsztein, D. C., Whittaker, J., Ffrench-Constant, C., Kershaw, A., Rosser, Anne Elizabeth, Bak, T. and Hodges, J. R. 2001. Psychiatric symptoms and CAG repeats in neurologically asymptomatic Huntington's disease gene carriers. Psychiatry Research 102 (3) , pp. 217-215.

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Abstract

The putative relationship between the psychiatric profile of a sample of neurologically asymptomatic Huntington's disease gene carriers and CAG repeats was investigated. The psychiatric assessments (by consultant psychiatrist and computerised battery) were undertaken before the genetic testing was carried out. In this way, the informational distortions caused by neurological and cognitive deficits were avoided. The hypothesis that there is a relationship between psychiatric and CAG repeats was tested by seeking direct correlations between psychiatric systems and CAG repeats, and also by correcting the correlation by the number of years above or below the estimated age of onset in Huntington's disease. Scores for irritability and cognitive failures were high in the sample. There was no correlation between any psychiatric variable and CAG repeats. Possible explanations for this lack of correlations are discussed.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Elsevier
ISSN: 0165-1781
Last Modified: 04 Jun 2017 08:35
URI: http://orca-mwe.cf.ac.uk/id/eprint/80716

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