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International union of basic and clinical pharmacology. XCVI. Pattern recognition receptors in health and disease

Bryant, Clare E., Orr, Selinda Jane, Ferguson, Brian, Symmons, Martyn F., Boyle, Joseph P. and Monie, Tom P. 2015. International union of basic and clinical pharmacology. XCVI. Pattern recognition receptors in health and disease. Pharmacological Reviews 67 (2) , pp. 462-504. 10.1124/pr.114.009928

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Abstract

Since the discovery of Toll, in the fruit fly Drosophila melanogaster, as the first described pattern recognition receptor (PRR) in 1996, many families of these receptors have been discovered and characterized. PRRs play critically important roles in pathogen recognition to initiate innate immune responses that ultimately link to the generation of adaptive immunity. Activation of PRRs leads to the induction of immune and inflammatory genes, including proinflammatory cytokines and chemokines. It is increasingly clear that many PRRs are linked to a range of inflammatory, infectious, immune, and chronic degenerative diseases. Several drugs to modulate PRR activity are already in clinical trials and many more are likely to appear in the near future. Here, we review the different families of mammalian PRRs, the ligands they recognize, the mechanisms of activation, their role in disease, and the potential of targeting these proteins to develop the anti-inflammatory therapeutics of the future.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine > RM Therapeutics. Pharmacology
Publisher: American Society for Pharmacology and Experimental Therapeutics
ISSN: 1521-0081
Funders: Wellcome Trust, MRC, Sir Henry Dale Fellowship
Last Modified: 07 Jun 2019 13:16
URI: http://orca-mwe.cf.ac.uk/id/eprint/80636

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