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Solid-supported iodonium salts for fluorinations

Edwards, Richard, de Vries, Wilke, Westwell, Andrew David, Daniels, Stephen and Wirth, Thomas 2015. Solid-supported iodonium salts for fluorinations. European Journal of Organic Chemistry 2015 (31) , pp. 6909-6916. 10.1002/ejoc.201500992

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Abstract

Solid-supported iodonium salt precursors have been prepared and used for the production of fluoroarenes. The importance of the resin functionality for the attachment of the iodonium salt moieties has been demonstrated. Furthermore, the production of new iodonium salt precursors for fluorination has been achieved by an alternative and improved method with respect to those previously described. The successful radiofluorination of a simple solid-supported precursor with no-carrier-added (n.c.a.) [18F]fluoride shows the suitability of the method for the production of useful PET synthons.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Medicine
Pharmacy
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: Solid-phase synthesis; Radiochemistry; Fluorine; Fluorination; Iodine; Hypervalent iodine
Publisher: Wiley
ISSN: 1434-193X
Date of First Compliant Deposit: 30 March 2016
Date of Acceptance: 12 August 2015
Last Modified: 27 Jun 2019 17:52
URI: http://orca-mwe.cf.ac.uk/id/eprint/80442

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