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The incidence of type 2 diabetes in the United Kingdom from 1991 to 2010

Holden, Sarah, Barnett, A.H., Peters, J.R., Jenkins-Jones, S., Poole, C.D., Morgan, Christopher and Currie, Craig 2013. The incidence of type 2 diabetes in the United Kingdom from 1991 to 2010. Diabetes, Obesity and Metabolism 15 (9) , pp. 844-852. 10.1111/dom.12123

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Abstract

Aims: To characterize the incidence of type 2 diabetes in the UK over the previous 20years; and determine if there has been an increase in people aged 40years or less at diagnosis. Methods: For this retrospective cohort study, patients newly diagnosed with type 2 diabetes between 1991 and 2010 were identified from the UK Clinical Practice Research Datalink (CPRD). Patient data were grouped into 5-year intervals by year of diagnosis and age at diagnosis. A standardized incidence ratio (SIR) was determined (1991-1995=100). The percentage of newly diagnosed patients for each age group and aged ≤40 years was calculated for each 5-year calendar period. The incidence rate by age and 5-year calendar period was also determined. Results: In 2010, the crude incidence rate of type 2 diabetes was 515 per 100,000 population. The overall SIR increased to 158 (95% CI 157-160, p<0.001), 237 (235-238, p<0.001) and 275 (273-276, p<0.001) for 1996-2000, 2001-2005 and 2006-2010, respectively. For those ≤40, the respective values were 217 (209-226, p<0.001), 327 (320-335, p<0.001) and 598 (589-608, p<0.001). An increase in incidence occurred with increasing 5-year calendar period. The incidence of type 2 diabetes was higher for males after the age of 40 and higher for females aged ≤40. The percentage of patients aged ≤40 years at diagnosis increased with each increasing 5-year calendar period (5.9, 8.4, 8.5 and 12.4%, respectively). Conclusions: There was a significant increase in the incidence of diagnosed type 2 diabetes between 1991 and 2010 and the proportion of people diagnosed at a relatively early age has increased markedly

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Adult; Age of Onset; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Early Diagnosis; Female; Great Britain; Hemoglobin A, Glycosylated; Humans; Incidence; Male; Registries; Retrospective Studies; Smoking
Publisher: Wiley and Blackwell
ISSN: 1462-8902
Date of Acceptance: 23 April 2013
Last Modified: 24 Dec 2017 20:51
URI: http://orca-mwe.cf.ac.uk/id/eprint/80107

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