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IFITM3 and susceptibility to respiratory viral infections in the community

Mills, Tara C., Rautanen, Anna, Elliott, Katherine S., Parks, Tom, Naranbhai, Vivek, Ieven, Margareta M., Butler, Christopher, Little, Paul, Verheij, Theo, Garrard, Chris S., Hinds, Charles, Goossens, Herman, Chapman, Stephen and Hill, Adrian V.S. 2014. IFITM3 and susceptibility to respiratory viral infections in the community. Journal of Infectious Diseases 209 (7) , pp. 1028-1031. 10.1093/infdis/jit468

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Interferon-inducible transmembrane proteins 1, 2, and 3 (IFITM 1,2, and 3) are viral restriction factors that mediate cellular resistance to several viruses. We have genotyped a possible splice-site altering single-nucleotide polymorphism (rs12252) in the IFITM3 gene in 34 patients with H1N1 influenza and severe pneumonia, and >5000 individuals comprising patients with community-acquired mild lower respiratory tract infection and matched controls of Caucasian ancestry. We found evidence of an association between rs12252 rare allele homozygotes and susceptibility to mild influenza (in patients attending primary care) but could not confirm a previously reported association between this single-nucleotide polymorphism and susceptibility to severe H1N1 infection.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: C Auxiliary Sciences of History > CS Genealogy
Q Science > QR Microbiology > QR355 Virology
Publisher: Oxford University Press
ISSN: 0022-1899
Date of Acceptance: 5 August 2013
Last Modified: 27 Mar 2019 17:31

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