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The future of biological agents in the treatment of rheumatoid arthritis

Rawlings, Charlotte and Choy, Ernest 2014. The future of biological agents in the treatment of rheumatoid arthritis. International Journal of Clinical Rheumatology 9 (5) , pp. 475-486. 10.2217/ijr.14.32

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Abstract

Rheumatoid arthritis (RA) is an autoimmune disease with a currently unknown etiology and multifactorial pathogenesis. This review recaps on the history of development of the main principles of biological disease-modifying agents. Moving into current treatment guidance from Europe and the USA, monotherapy and second-line biological choice is addressed. The reviews explores and summarizes the latest developments and potential impact of anti-cytokine therapy, including TNF, IL-6 and IL-17, anti-lymphocyte therapies, B cell modulators and other B-cell targets, anti-CD3, biosimilars and finally oral agents such as JAK and Syk inhibitors.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
Publisher: Future Medicine
ISSN: 1758-4272
Last Modified: 04 Apr 2020 01:28
URI: http://orca-mwe.cf.ac.uk/id/eprint/78669

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