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Epilepsy and bipolar disorder

Knott, Sarah, Forty, Elizabeth, Craddock, Nicholas John and Thomas, Rhys Huw 2015. Epilepsy and bipolar disorder. Epilepsy & Behavior 52 , pp. 267-274. 10.1016/j.yebeh.2015.07.003

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Abstract

It is well recognized that mood disorders and epilepsy commonly co-occur. Despite this, our knowledge regarding the relationship between epilepsy and bipolar disorder is limited. Several shared features between the two disorders, such as their episodic nature and potential to run a chronic course, and the efficacy of some antiepileptic medications in the prophylaxis of both disorders, are often cited as evidence of possible shared underlying pathophysiology. The present paper aims to review the bidirectional associations between epilepsy and bipolar disorder, with a focus on epidemiological links, evidence for shared etiology, and the impact of these disorders on both the individual and wider society. Better recognition and understanding of these two complex disorders, along with an integrated clinical approach, are crucial for improved evaluation and management of comorbid epilepsy and mood disorders.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Bipolar disorder; Genetics; Epilepsy; Comorbidity
Publisher: Elsevier
ISSN: 1525-5050
Date of Acceptance: 2 July 2015
Last Modified: 20 Jun 2019 20:36
URI: http://orca-mwe.cf.ac.uk/id/eprint/78492

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