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Pattern recognition analysis of anterior cingulate cortex blood flow to classify depression polarity

Almeida, J. R. C., Mourao-Miranda, J., Aizenstein, H. J., Versace, A., Kozel, F. A., Lu, H., Marquand, A., LaBarbara, E. J., Brammer, M., Trivedi, M., Kupfer, D. J. and Phillips, M. L. 2013. Pattern recognition analysis of anterior cingulate cortex blood flow to classify depression polarity. British Journal of Psychiatry 203 (4) , pp. 310-1. 10.1192/bjp.bp.112.122838

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Abstract

Differentiating bipolar from recurrent unipolar depression is a major clinical challenge. In 18 healthy females and 36 females in a depressive episode--18 with bipolar disorder type I, 18 with recurrent unipolar depression--we applied pattern recognition analysis using subdivisions of anterior cingulate cortex (ACC) blood flow at rest, measured with arterial spin labelling. Subgenual ACC blood flow classified unipolar v. bipolar depression with 81% accuracy (83% sensitivity, 78% specificity).

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Royal College of Psychiatrists
ISSN: 0007-1250
Last Modified: 14 Sep 2015 13:00
URI: http://orca-mwe.cf.ac.uk/id/eprint/76706

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