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CD1d-lipid antigen recognition by the γδTCR

Uldrich, A., Le Nours, J., Pellicci, D., Gherardin, N., McPherson, K., Lim, R., Patel, O., Beddoe, T., Gras, S., Rossjohn, Jamie and Godfrey, D. 2013. CD1d-lipid antigen recognition by the γδTCR. Nature Immunology 14 (11) , pp. 1137-1145. 10.1038/ni.2713

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Abstract

The T cell repertoire comprises αβ and γδ T cell lineages. Although it is established how αβ T cell antigen receptors (TCRs) interact with antigen presented by antigen-presenting molecules, this is unknown for γδ TCRs. We describe a population of human V δ 1 + γδ T cells that exhibit autoreactivity to CD1d and provide a molecular basis for how a γδ TCR binds CD1d-α- galactosylceramide (α-GalCer). The γδ TCR docked orthogonally, over the A′ pocket of CD1d, in which the V δ 1-chain, and in particular the germ line-encoded CDR1δ loop, dominated interactions with CD1d. The TCR γ-chain sat peripherally to the interface, with the CDR3γ loop representing the principal determinant for α-GalCer specificity. Accordingly, we provide insight into how a γδ TCR binds specifically to a lipid-loaded antigen-presenting molecule.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Uncontrolled Keywords: Amino Acid Sequence; Antigens, CD1d; Binding Sites; Databases, Protein; Galactosylceramides; Humans; Molecular Docking Simulation; Molecular Sequence Data; Protein Binding; Protein Structure, Tertiary; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocyte Subsets
Publisher: Nature Publishing Group
ISSN: 1529-2908
Date of Acceptance: 19 August 2013
Last Modified: 04 Jun 2017 08:20
URI: http://orca-mwe.cf.ac.uk/id/eprint/75958

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