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NO DOI! Regulation of the expression of E-cadherin on human cancer cells by gamma-linolenic acid (GLA)

Jiang, W. G., Hiscox, S., Hallett, Maurice Bartlett, Horrobin, D. F., Mansel, R. E. and Puntis, M. C. 1995. NO DOI! Regulation of the expression of E-cadherin on human cancer cells by gamma-linolenic acid (GLA). Cancer Research 55 (21) , pp. 5043-5048.

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Abstract

E-cadherin is a cell to cell adhesion molecule which acts as a suppressor of metastasis. This study examined the effect of gamma-linolenic acid (GLA), a n-6 polyunsaturated fatty acid, on the expression of E-cadherin in human cancer cells. Western blotting studies demonstrated that treatment of cells with GLA for 24 h increased the expression of E-cadherin in lung, colon, breast, melanoma, and liver cancer cells, but not in endothelial cells and fibroblasts. The results were confirmed by immunocytochemistry. In contrast, two other n-6 fatty acids, linoleic acid and arachidonic acid, failed to induce these changes. The increased expression of E-cadherin was correlated with reduced in vitro invasion and increased aggregation, indicating that the increased E-cadherin expression induced by GLA was biologically active. These data add GLA to the short list of E-cadherin up-regulatory factors. The up-regulation of E-cadherin expression in human cancer cells may contribute to the anticancer properties of GLA.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Antineoplastic Agents/pharmacology*, Arachidonic Acid/pharmacology, Blotting, Western, Cadherins/metabolism, Cadherins/physiology*, Cell Aggregation/drug effects, Cell Aggregation/physiology, Humans, Immunohistochemistry, Linoleic Acid, Linoleic Acids/pharmacology, Neoplasm Invasiveness, Neoplasms/drug therapy, Neoplasms/metabolism*, Neoplasms/pathology, Tumor Cells, Cultured/drug effects, gamma-Linolenic Acid/pharmacology*
Publisher: American Association for Cancer Research
ISSN: 0008-5472
Last Modified: 04 Jun 2017 08:20
URI: http://orca-mwe.cf.ac.uk/id/eprint/75900

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