Structure and role of WASP and WAVE in Rho GTPase signalling in cancer

Lane, Jane ORCID: https://orcid.org/0000-0002-1926-4909, Martin, Tracey Amanda ORCID: https://orcid.org/0000-0003-2690-4908, Weeks, Hoi Ping and Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 2014. Structure and role of WASP and WAVE in Rho GTPase signalling in cancer. Cancer Genomics and Proteomics 11 (3) , pp. 155-165.

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Abstract

A major factor controlling the metastatic nature of cancer cells is their motility. Alterations in the signalling pathways controlling its regulation can lead to tumor cell invasion and metastasis. Directional motility involves protrusion of the cell’s leading edge, via formation of filopodia and lamellipodia, adhesion to the substrate followed by tail retraction and de-adhesion. Rho GTPase binding proteins function as activators of the actin cytoskeleton and are key players in the transendothelial migration of cancer cells. Activation of the specific GTPases Rho, Rac1 and Cdc42 results in formation of actin stress fibres, membrane ruffles, lamellipodia and filopodia respectively and in cortical actin assembly. Pathways through which Rho GTPases elicit these effects are through direct interaction with members of the Wiskott-Alrich Syndrome Protein (WASP) family which stimulates structures such as lamellipodia and filopodia. The present review explores the role and function of Rho GTPases, WASP and WAVE in cancer metastasis.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	International Institute of Anticancer Research
ISSN:	1109-6535
Date of Acceptance:	16 June 2014
Last Modified:	16 Nov 2022 07:28
URI:	https://orca.cardiff.ac.uk/id/eprint/75800

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