Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Assessment of pulmonary artery pulse wave velocity in children: An MRI pilot study

Poon, Chuen Y., Edwards, Julie May, Evans, C. John, Harris, Ashley D., Tsai-Goodman, Beverly, Bolton, Charlotte E., Cockcroft, John Ronald, Wise, Richard Geoffrey and Kotecha, Sailesh 2013. Assessment of pulmonary artery pulse wave velocity in children: An MRI pilot study. Magnetic Resonance Imaging 31 (10) , pp. 1690-1694. 10.1016/j.mri.2013.08.006

Full text not available from this repository.

Abstract

Purpose To assess the feasibility of measuring pulmonary artery (PA) pulse wave velocity (PWV) in children breathing ambient air and 12% oxygen. Methods Velocity-encoded phase-contrast MR images of the PA were acquired in 15 children, aged 9–12 years, without evidence of cardiac or pulmonary diseases. PWV was derived as the ratio of flow to area changes during early systole. Each child was scanned twice, in air and after at least 20 minutes into inspiratory hypoxic challenge. Intra-observer and inter-observer variability and repeatability were also compared. Results PA PWV, which was successfully measured in all subjects, increased from 1.31 ± 0.32 m/s in air to 1.61 ± 0.58 m/s under hypoxic challenge (p = 0.03). Intra- and inter-observer coefficients of variations were 9.0% and 15.6% respectively. Good correlation within and between observers of r = 0.92 and r = 0.72 respectively was noted for PA PWV measurements. Mean (95% limit of agreement) intra- and inter-observer agreement on Bland–Altman analysis were − 0.02 m/s (− 0.41–0.38 m/s) and -0.28 m/s (− 1.06–0.49 m/s). Conclusion PA PWV measurement in children using velocity-encoded MRI is feasible, reproducible and sufficiently sensitive to detect differences in PA compliance between normoxia and hypoxia. This technique can be used to detect early changes of PA compliance and monitor PAH in children.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Psychology
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Velocity-encoded MRI; Pulse wave velocity; Pulmonary artery; Children; Hypoxia
Publisher: Elsevier
ISSN: 0730-725X
Last Modified: 04 Jun 2017 08:17
URI: http://orca-mwe.cf.ac.uk/id/eprint/75485

Citation Data

Cited 7 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item