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Brain MR spectroscopy in autism spectrum disorder - the GABA excitatory/inhibitory imbalance theory revisited

Brix, Maiken K., Ersland, Lars, Hugdahl, Kenneth, Grüner, Renate, Posserud, Maj-Britt, Hammar, Åsa, Craven, Alexander R., Noeske, Ralph, Evans, Christopher John, Walker, Hanne B., Midtvedt, Tore and Beyer, Mona K. 2015. Brain MR spectroscopy in autism spectrum disorder - the GABA excitatory/inhibitory imbalance theory revisited. Frontiers in Human Neuroscience 9 , 00365. 10.3389/fnhum.2015.00365

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Abstract

Magnetic resonance spectroscopy (MRS) from voxels placed in the left anterior cingulate cortex (ACC) was measured from 14 boys with Autism Spectrum Disorder (ASD) and 24 gender and age-matched typically developing (TD) control group. Our main aims were to compare the concentration of γ-aminobutyric acid (GABA) between the two groups, and to investigate the relationship between brain metabolites and autism symptom severity in the ASD group. We did find a significant negative correlation in the ASD group between Autism Spectrum Screening Questionnaire (ASSQ) and GABA+/Cr, which may imply that severity of symptoms in ASD is associated with differences in the level of GABA in the brain, supporting the excitatory/inhibitory (E/I) imbalance theory. However we did not find a significant difference between the two groups in GABA levels.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Cardiff University Brain Research Imaging Centre (CUBRIC)
Psychology
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Additional Information: This Document is protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission
Publisher: Frontiers Research Foundation
ISSN: 1662-5161
Date of First Compliant Deposit: 30 March 2016
Date of Acceptance: 8 June 2015
Last Modified: 06 Mar 2019 14:28
URI: http://orca-mwe.cf.ac.uk/id/eprint/74987

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