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Novel bicyclic furanopyrimidines with dual anti-VZV and -HCMV activity

McGuigan, Christopher, Brancale, Andrea, Andrei, Graciela, Snoeck, Robert, De Clercq, Erik and Balzarini, Jan 2003. Novel bicyclic furanopyrimidines with dual anti-VZV and -HCMV activity. Bioorganic & Medicinal Chemistry Letters 13 (24) , pp. 4511-4513. 10.1016/j.bmcl.2003.08.028

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Abstract

Several novel bicyclic furanopyrimidine deoxy nucleosides have been designed, prepared and evaluated as anti-Varicella Zoster Virus agents. The compounds have long ether side chains. Uniquely amongst compounds of this family to date the present agents show dual anti- (VZV) and human cytomegalovirus (HCMV) activity. The lead compounds inhibit VZV at 10 nM and HCMV at 5 μM.

Item Type: Article
Status: Published
Schools: Pharmacy
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
R Medicine > RS Pharmacy and materia medica
ISSN: 0960-894X
Last Modified: 18 Oct 2017 13:44
URI: http://orca-mwe.cf.ac.uk/id/eprint/7488

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