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Molecular modelling studies on Arylthioindoles as potent inhibitors of tubulin polymerization

Coluccia, Antonio, Sabbadin, Davide and Brancale, Andrea 2011. Molecular modelling studies on Arylthioindoles as potent inhibitors of tubulin polymerization. European Journal of Medicinal Chemistry 46 (8) , pp. 3519-3525. 10.1016/j.ejmech.2011.05.020

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Abstract

The crucial role played by microtubules in the life of eukaryotic cell makes tubulin an important route for the anticancer therapy. The Arylthioindoles (ATIs) along with the corresponding ketone and methylene compounds are potent tubulin assembly inhibitors. We are here reporting the result of a series of docking and molecular dynamics experiments on this series of compounds. The results obtained from our in silico studies not only provided us with an insight on the nature of the binding of the ATIs to tubulin, but were also at the core of the design of a new series of potent inhibitors of tubulin polymerization.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RS Pharmacy and materia medica
Uncontrolled Keywords: tubulin ; colchicine ; arylthioindole ; docking; molecular dynamics.
Publisher: Elsevier
ISSN: 0223-5234
Last Modified: 04 Jun 2017 02:00
URI: http://orca-mwe.cf.ac.uk/id/eprint/7460

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