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Asymmetric Michael Addition-Lactonization of Carboxylic Acids

Belmessieri, D., Morrill, Louis, Simal, C., Slawin, A. M. Z. and Smith, A. D. 2011. Asymmetric Michael Addition-Lactonization of Carboxylic Acids. Synfacts 2011 (04) , 0436. 10.1055/s-0030-1259622

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Abstract

A highly efficient asymmetric intra- and intermolecular Michael addition-lactonization of a variety of enone acids, arylacetic acids, and α-keto-β,γ-unsaturated esters using chiral isothioureas as catalysts was reported. The combination of an activating agent and the catalyst was crucial to generate an efficient catalytic cycle. To further demonstrate the utility of this process, the authors performed a simple derivatization of the products to obtain indene carboxylates in good yields and high enantioselectivities.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: Thieme Publishing
ISSN: 1861-1958
Last Modified: 04 Jun 2017 08:12
URI: http://orca-mwe.cf.ac.uk/id/eprint/74310

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