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Reply to Liu et al.: Loss of TGF-β signaling in CARASIL pathogenesis

Beaufort, Nathalie, Scharrer, Eva, Lux, Vanda, Ehrmann, Michael, Haffner, Christof and Dichgans, Martin 2015. Reply to Liu et al.: Loss of TGF-β signaling in CARASIL pathogenesis. Proceedings of the National Academy of Sciences of the United States of America 112 (14) , E1694. 10.1073/pnas.1501817112

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We thank Liu et al. (1) for their comments on our work on the link between the cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL)-related protease high temperature requirement protein A1 (HtrA1) and the TGF-β signaling pathway. To advance our understanding of the mechanisms underlying HtrA1 deficiency, we used dermal fibroblasts from CARASIL patients and Htra1 knockout mice as experimental systems (2). We agree with Liu et al. that findings from fibroblasts might or might not fully reflect the physiological processes occurring in a vessel wall and that alterations in other cell types …

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QR Microbiology
Publisher: National Academy of Sciences
ISSN: 0027-8424
Last Modified: 14 Mar 2019 15:37

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