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Predisposed αβ T cell antigen receptor recognition of MHC and MHC-I like molecules?

Eckle, S. B., Turner, S. J., Rossjohn, Jamie and McCluskey, J. 2013. Predisposed αβ T cell antigen receptor recognition of MHC and MHC-I like molecules? Current Opinion in Immunology 25 (5) , pp. 653-659. 10.1016/j.coi.2013.07.010

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Abstract

The diverse αβ T cell receptor (TCR) repertoire exhibits versatility in its ability to generate antigen (Ag) receptors capable of interacting with polymorphic Major Histocompatibility Complex (MHC) molecules and monomorphic MHC-I like molecules, including the CD1 and MR1 families. Collectively, these evolutionarily related Ag-presenting molecules present peptides, lipids and vitamin B metabolites for T cell surveillance. Interestingly, whilst common TCR gene usage can underpin recognition of these distinct classes of Ags, it is unclear whether the 'rules' that govern αβTCR-Ag MHC interactions are shared. We highlight recent observations in the context of TCR biases towards MHC and MHC-I like molecules.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Publisher: Elsevier
ISSN: 0952-7915
Last Modified: 04 Jun 2017 08:11
URI: http://orca-mwe.cf.ac.uk/id/eprint/73885

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