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Cross-linking of CD11b or CD18 signals release of localized Ca2+ from intracellular stores in neutrophils

Petersen, M., Williams, J. D. and Hallett, Maurice Bartkett 1993. Cross-linking of CD11b or CD18 signals release of localized Ca2+ from intracellular stores in neutrophils. Immunology 80 (1) , pp. 157-159.

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Abstract

Cross-linking of antibodies bound to CD11b or CD18 on the neutrophil surface produced a large Ca2+ transient (max. approximately 500 nM). The major source for this Ca2+ rise (more than 81%) was from an intracellular Ca2+ store. After integrin cross-linking, the Ca2+ transient induced by N-formyl-methionyl-leucyl-phenylalanine (FMLP) was decreased, suggesting that both stimuli acted on the same Ca2+ store. Release from the Ca2+ store, induced by integrin cross-linking, was visualized as a 'cloud' of elevated Ca2+, which remained localized even in the presence of extracellular Ca2+. The generation of localized cytosolic Ca2+ signals by cross-linking integrin may be important for triggering localized cellular responses

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Wiley Blackwell
ISSN: 0019-2805
Related URLs:
Last Modified: 04 Jun 2017 08:08
URI: http://orca-mwe.cf.ac.uk/id/eprint/73183

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