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Inhibition of neutrophil respiratory burst and cytokine priming by γ-linolenic acid

Jiang, Wen Guo, Puntis, M. C. A., Horrobin, D. F., Scott, C. and Hallett, Maurice Bartlett 1996. Inhibition of neutrophil respiratory burst and cytokine priming by γ-linolenic acid. British Journal of Surgery 83 (5) , pp. 659-664. 10.1002/bjs.1800830523

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Abstract

The effect of n-6 fatty acids, particularly y-linolenic acid (GLA), on the oxidase response and neutrophil priming by tumour necrosis factor a and interleukin 8 was studied in both normal volunteers and patients with obstructive jaundice. GLA inhibited the neutrophil respiratory burst at concentrations higher than 50 μmol/l, but abolished cytokine priming at concentrations as low as 1 μmmol/1. Inhibition was not the result of either cytotoxicity to the neutrophils or alteration in cytosolic free calcium homoeostasis. It is concluded that GLA is a potential inhibitor of neutrophil priming by cytokines and of the oxidative response.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Wiley-Blackwell
ISSN: 0007-1323
Last Modified: 06 Sep 2017 10:27
URI: http://orca-mwe.cf.ac.uk/id/eprint/73140

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