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NO DOI! The microanatomy of calcium stores in human neutrophils: relationship of structure to function

Pettit, E. J., Davies, E. V. and Hallett, Maurice Bartlett 1997. NO DOI! The microanatomy of calcium stores in human neutrophils: relationship of structure to function. Histology and Histopathology 12 (2) , pp. 479-490.

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Abstract

As changes in cytosolic free Ca2+ play key roles in coupling responses in neutrophils, it is important to locate and identify Ca2+ storage sites within these cells. Here, recent data is presented which highlights the functional link between microanatomical structure and cell signalling function. Fluorescent optical probes for cytosolic free Ca2+ have been used, together with organelle specific markers. We present evidence from conventional fluorescence microscopy, together with ratiometric and confocal laser scanning fluorescence microscopy, which pin-points two cellular locations for Ca2+ within the neutrophil; one within the nuclear lobes, and the other towards the cell periphery. Knowledge of these two locations provides a clear insight into how signalling in this cell type is regulated and provides a framework for explaining how specific stimuli act to produce specific responses

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Animals, Calcium/metabolism, Calcium/physiology, Humans, Neutrophils/metabolism, Neutrophils/physiology, Neutrophils/ultrastructure, Signal Transduction/physiology
Publisher: Murcia, Spain : Gutenberg
ISSN: 0213-3911
Last Modified: 04 Jun 2017 08:07
URI: http://orca-mwe.cf.ac.uk/id/eprint/73135

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