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Spatial and temporal separation of calcium signals in myeloid cells stimulated by immune complexes

Davies, E. V., Roberts, G. M. and Hallett, Maurice Bartlett 1997. Spatial and temporal separation of calcium signals in myeloid cells stimulated by immune complexes. Cellular Signalling 9 (6) , pp. 457-462. 10.1016/S0898-6568(97)00039-9

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Abstract

Stimulation of large (100 μm) human myeloid cells with immune complexes resulted in Ca2+ spiking. Both global and regional changes in the intracellular cytosolic free Ca2+ concentration were detected in response to immune complex stimulation. The regional changes were mediated by release of Ca2+ from stores, whereas global changes were mediated by Ca2+ influx. They occurred independently of each other, with release of Ca2+ from intracellular Ca2+ stores being separated from transmembrane influx of Ca2+. Bromophenacyl bromide, an l-plastin binding agent, inhibited store release without preventing transmembrane influx of Ca2+. The large size of the myeloid cells used here allowed the visualisation of the spatial and temporal separation of store release from transmembrane influx of Ca2+, providing further evidence for the existence of independent Ca2+ store release and Ca2+ influx mechanisms in these cells.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Elsevier
ISSN: 0898-6568
Last Modified: 04 Jun 2017 08:07
URI: http://orca-mwe.cf.ac.uk/id/eprint/73123

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